Chemokines as effector and target molecules in vascular biology
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چکیده
منابع مشابه
Platelet-derived chemokines in vascular biology.
Undoubtedly, platelets are key elements in the regulation of thrombosis and haemostasis. Along with their primary task to prevent blood loss from injured vessels, platelets have emerged as regulators of a variety of processes in the vasculature. Multiple challenges, from the contact and adhesion to subendothelial matrix after injury of the vessel wall, to interactions with blood cells in inflam...
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Thromb Haemost 2007; 97: 685–687 The trafficking and extravasation of leukocytes during immune surveillance and inflammation is governed by the chemokine family of small chemotactic peptides. The structural classification of chemokines, their cognate heptahelical receptors, expression patterns and biological functions in immune cell regulation during health and disease have been critically revi...
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The trafficking of leukocytes is essential for many aspects of vascular biology and pathology in health and disease. Sequential steps of leukocyte recruitment to the vascular wall, eg, adhesion and emigration, are governed by chemokines, a family of small chemotactic peptides, which serve both inflammatory and homeostatic functions. Beyond controlling the extravasation, patrolling, and subseque...
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A new generation of strategies is evolving that aim to block malaria transmission by employing genetically modified vectors or mosquito pathogens or symbionts that express anti-parasite molecules. Whilst transgenic technologies have advanced rapidly, there is still a paucity of effector molecules with potent anti-malaria activity whose expression does not cause detrimental effects on mosquito f...
متن کاملChemokines in vascular remodeling.
The arterial vessel wall response to a variety of injuries consists in structural changes, which can result in luminal narrowing and aggravation of the underlying disease. This arterial remodeling is characterized by neointima formation and medial thickening, inflammatory cell recruitment and endothelial dysfunction. Chemokines and the corresponding receptors have been shown to participate at e...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2015
ISSN: 0008-6363,1755-3245
DOI: 10.1093/cvr/cvv150